Publications

 

Frankel Lab publications can be found in PubMed:

https://www.ncbi.nlm.nih.gov/sites/myncbi/alan.frankel.2/collections/61836112/public/

 

Selected recent publications:

Safari, M., Jayaraman, B., Yang, S., Smith, C., Fernandes, J.D., Frankel, A.D. (2022) Functional and Structural Segregation of Overlapping Helices in HIV-1. Elife. 11:e72482. doi: 10.7554/eLife.72482

 

Johnson JR, Crosby DC, Hultquist JF, Kurland AP, Adhikary P, Li D, Marlett J, Swann J, Hüttenhain R, Verschueren E, Johnson TL, Newton BW, Shales M, Simon VA, Beltrao P, Frankel AD, Marson A, Cox JS, Fregoso OI, Young JAT, Krogan NJ. (2022) Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling. Cell Rep. 39:110690. doi: 10.1016/j.celrep.110690

 

Gordon, D.E., Watson, A., Roguev, A., Zheng, S., Jang, G.M., Kane, J., Xu, J., Guo, J.Z., Stevenson, E., Swaney, D.L., Franks-Skiba, K., Verschueren, E., Shales, M., Crosby, D.C., Frankel, A.D., Marson, A., Marazzi, I., Cagney, G., Krogan, N.J. (2020) A Quantitative Genetic Interaction Map of HIV Infection. Mol Cell. 78:197-209

 

Gordon, D.E., Jang, G.M., Bouhaddou, M., Xu, J., Obernier, K., White, K.M., O'Meara, M.J., Rezelj, V.V., Guo, J.Z., Swaney, D.L., Tummino, T.A., Hüttenhain, R., Kaake, R.M., Richards, A.L., Tutuncuoglu, B., Foussard, H., Batra, J., Haas, K., Modak, M., Kim, M., Haas, P., Polacco, B.J., Braberg, H., Fabius, J.M., Eckhardt, M., Soucheray, M., Bennett, M.J., Cakir, M., McGregor, M.J., Li, Q., Meyer, B., Roesch, F., Vallet, T., Mac Kain, A., Miorin, L., Moreno, E., Naing, Z.Z.C., Zhou, Y., Peng, S., Shi, Y., Zhang, Z., Shen, W., Kirby, I.T., Melnyk, J.E., Chorba, J.S., Lou, K., Dai, S.A., Barrio-Hernandez, I., Memon, D., Hernandez-Armenta, C., Lyu, J., Mathy, C.J.P., Perica, T., Pilla, K.B., Ganesan, S.J., Saltzberg, D.J., Rakesh, R., Liu, X., Rosenthal, S.B., Calviello, L., Venkataramanan, S., Liboy-Lugo, J., Lin, Y., Huang, X.P., Liu, Y., Wankowicz, S.A., Bohn, M., Safari, M., Ugur, F.S., Koh, C., Savar, N.S., Tran, Q.D., Shengjuler, D., Fletcher, S.J., O'Neal, M.C., Cai, Y., Chang, J.C.J., Broadhurst, D.J., Klippsten, S., Sharp, P.P., Wenzell, N.A., Kuzuoglu-Ozturk, D., Wang, H.Y., Trenker, R., Young, J.M., Cavero, D.A., Hiatt, J., Roth, T.L., Rathore, U., Subramanian, A., Noack, J., Hubert, M., Stroud, R.M., Frankel, A.D., Rosenberg, O.S., Verba, K.A., Agard, DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz, O., d'Enfert, C., Mukherjee, S., Jacobson, M., Malik, H.S., Fujimori, D.G., Ideker, T., Craik, C.S., Floor, S.N., Fraser, J.S., Gross, J.D., Sali, A., Roth, B.L., Ruggero, D., Taunton, J., Kortemme, T., Beltrao, P., Vignuzzi, M., García-Sastre, A., Shokat, K.M., Shoichet, B.K., Krogan, N.J. (2020) A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 583:459-468

 

Carlson, C.R., Asfaha, J.B., Ghent, C.M., Howard, C.J., Hartooni, N., Safari, M., Frankel, A.D., Morgan, D.O. (2020) Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions. Mol Cell. 80:1092-1103

 

Jayaraman, B., Fernandes, J.D., Yang, S., Smith, C., Frankel, A.D. (2019) Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability. Sci Rep. 9:5139. doi: 10.1038/s41598-019-41582-7

 

Hüttenhain, R., Xu, J., Burton, L.A., Gordon, D.E., Hultquist, J.F., Johnson, J.R., Satkamp, L., Hiatt, J., Rhee, D.Y., Baek, K., Crosby, D.C., Frankel, A.D., Marson, A., Harper, J.W., Alpi, A.F., Schulman, B.A., Gross, J.D., Krogan, N.J. (2019) ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Cell Host Microbe. 26:86-99

 

Faust, T.B., Li, Y., Bacon, C.W., Jang, G.M., Weiss, A., Jayaraman, B., Newton, B.W., Krogan, N.J., D'Orso, I., Frankel, A.D. (2018) The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife. 7:e31879. doi: 10.7554/eLife.31879

 

Faust, T.B., Li, Y., Jang, G.M., Johnson, J.R., Yang. S., Weiss, A., Krogan, N.J., Frankel, A.D. (2017) PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription. Sci Rep. 7:45394. doi: 10.1038/srep45394

 

Fernandes, J.D., Faust, T.B., Strauli, N.B., Smith, C., Crosby, D.C., Nakamura, R.L., Hernandez, R.D., Frankel, A.D. (2016) Functional Segregation of Overlapping Genes in HIV. Cell. 167:1762-1773

 

Jayaraman, B., Crosby, D.C., Homer, C., Ribeiro, I., Mavor, David, Frankel, A.D. (2014) RNA-directed remodeling of the HIV-1 Rev protein orchestrates assembly of the Rev-Rev response element complex. eLife:10.7554/eLife.04120

 

Booth, D.S., Cheng, Y., Frankel, A.D. (2014) The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA. eLife:10.7554/eLife.04121

 

D'Orso, I., Jang, G.M., Pastuszak, A.W., Faust, T. B., Quezada, E., Booth, D.S., Frankel, A.D. (2012)  A transition step during assembly of HIV Tat-P-TEFb transcription complexes and transfer to TAR. Mol. Cell Biol. 32:4780-4793.

 

Jäger, S., Cimermancic, P., Gulbahce, N., Johnson, J., McGovern, K., Clarke, S., Shales, M., Mercenne, G., Pache, L., Li, K., Barry, H., Jang, G.M., Roths, S., Akiva, E., Marlett, J., Stephens, M. D’Orso, I., Fernandes, J., Fahey, M., Mahon, C., O’Donoghue, A., Todorovic, A., Morris, J.H., Maltby, D., Alber, T., Cagney, G., Bushman, F.D., Young, J.A., Chanda, S.K., Sundquist, W.I., Kortemme, T., Hernandez, R.D., Craik, C.S., Burlingame, A., Sali, A., Frankel, A.D., and Krogan, N.J. (2011) Global Landscape of HIV-Human Protein Complexes. Nature 481:365-370

 

Daugherty, M.D., Liu, B., Frankel, A.D. (2010) Structural basis for cooperative RNA binding and export complex assembly by HIV Rev. Nat. Struct. Mol. Biol. 17:1337-1342

 

Daugherty, M.D., Booth, D.S., Jayaraman, B., Cheng, Y., Frankel, A.D. (2020) HIV Rev response element (RRE) directs assembly of the Rev homooligomer into discrete asymmetric complexes. Proc Natl Acad Sci USA 107:12481-12486

 

D'Orso, I., Frankel, A.D. (2010) RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation. Nat Struct Mol Biol. 17:815-821

 

D'Orso, I. and Frankel, A. D. (2009) Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex, Proc. Natl. Acad. Sci. USA 106:3101-3106

 

Daugherty, M. D., D'Orso, I., and Frankel, A. D. (2008) A solution to limited genomic capacity: Using adaptable binding surfaces to assemble the function HIV Rev oligomer on RNA, Mol. Cell 31: 824-834